Musk CLIA Kit for Mouse(Mus musculus) | EIAab.comMusk CLIA Kit for Mouse(Mus musculus)

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Musk (Gene name),

Muscle, skeletal receptor tyrosine-protein kinase (Protein name ), MUSK_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Musk(Nsk2);

Protein name:

Muscle, skeletal receptor tyrosine-protein kinase;

Alternative:

Muscle-specific tyrosine-protein kinase receptor(MuSK;Muscle-specific kinase receptor);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Monomer. Homodimer (Probable). Interacts with DOK7. Interaction with DOK7 promotes activation by tyrosine phosphorylation. Interacts with PDZRN3; this interaction is enhanced by agrin. Interacts with RNF31.

Function:

Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization.

Subcellular Location:

Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

868

Sequence:

50:

100:

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250:

300:

350:

400:

450:

500:

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650:

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800:

850:

868:

IHRILQRMCE | RAEGTVGV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q61006

Pfam:

PF01392

KEGG:

mmu:18198

UniGene:

Mm.16148

SMR:

Q61006

Uniprot:

Q61006

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ELISA Kit for Mouse Muscle, skeletal receptor tyrosine-protein kinase

Cat.:

E0992h

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96T

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ELISA Kit for Mouse Muscle, skeletal receptor tyrosine-protein kinase

Cat.:

E0992m

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96T

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ELISA Kit for Mouse Muscle, skeletal receptor tyrosine-protein kinase

Cat.:

E0992c

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Muscle, skeletal receptor tyrosine-protein kinase

Cat.:

E0992r

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96T

CLIA Kit for Mouse Muscle, skeletal receptor tyrosine-protein kinase

Cat.:

U0992c

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Muscle, skeletal receptor tyrosine-protein kinase

Cat.:

U0992m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Muscle, skeletal receptor tyrosine-protein kinase

Cat.:

U0992r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Muscle, skeletal receptor tyrosine-protein kinase

Cat.:

U0992h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Mouse Muscle, skeletal receptor tyrosine-protein kinase

Cat.:

P0992Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Muscle, skeletal receptor tyrosine-protein kinase

Cat.:

P0992Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse Muscle, skeletal receptor tyrosine-protein kinase

Cat.:

P0992Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Muscle, skeletal receptor tyrosine-protein kinase

Monoclonal Antibody for Mouse Muscle, skeletal receptor tyrosine-protein kinase

Protein for Mouse Muscle, skeletal receptor tyrosine-protein kinase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

Caruso A. , Morris J.C. , Neben S. , Finnerty H. , Beier D. , Turner K. , Wood C.R.
Submitted (1995-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
2.

"Cloning and developmental expression of Nsk2, a novel receptor tyrosine kinase implicated in skeletal myogenesis."
Ganju P. , Walls E. , Brennan J. , Reith A.D.
Oncogene11:281-290(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 3 AND 4);DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
tissue: Myoblast.
3.

"The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo."
DeChiara T.M. , Bowen D.C. , Valenzuela D.M. , Simmons M.V. , Poueymirou W.T. , Thomas S. , Kinetz E. , Compton D.L. , Rojas E. , Park J.S. , Smith C. , DiStefano P.S. , Glass D.J. , Burden S.J. , Yancopoulos G.D.
Cell85:501-512(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION IN NEUROMUSCULAR JUNCTION DEVELOPMENT
4.

"Agrin acts via a MuSK receptor complex."
Glass D.J. , Bowen D.C. , Stitt T.N. , Radziejewski C. , Bruno J. , Ryan T.E. , Gies D.R. , Shah S. , Mattsson K. , Burden S.J. , DiStefano P.S. , Valenzuela D.M. , DeChiara T.M. , Yancopoulos G.D.
Cell85:513-523(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF AGRIN AS LIGAND;IDENTIFICATION OF THE AGRIN RECEPTOR COMPLEX;PHOSPHORYLATION
5.

"Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse."
Lin W. , Burgess R.W. , Dominguez B. , Pfaff S.L. , Sanes J.R. , Lee K.F.
Nature410:1057-1064(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACETYLCHOLINE RECEPTOR CLUSTERING
6.

"Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1."
Luo Z.G. , Wang Q. , Zhou J.Z. , Wang J. , Luo Z. , Liu M. , He X. , Wynshaw-Boris A. , Xiong W.C. , Lu B. , Mei L.
Neuron35:489-505(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DVL1 AND PAK1
7.

"A novel pathway for MuSK to induce key genes in neuromuscular synapse formation."
Lacazette E. , Le Calvez S. , Gajendran N. , Brenner H.R.
J. Cell Biol.161:727-736(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TRANSCRIPTION REGULATION
8.

"Implication of geranylgeranyltransferase I in synapse formation."
Luo Z.G. , Je H.S. , Wang Q. , Yang F. , Dobbins G.C. , Yang Z.H. , Xiong W.C. , Lu B. , Mei L.
Neuron40:703-717(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RAC1 ACTIVATION;FUNCTION IN PHOSPHORYLATION OF FNTA;INTERACTION WITH FNTA
9.

"A putative ariadne-like E3 ubiquitin ligase (PAUL) that interacts with the muscle-specific kinase (MuSK)."
Bromann P.A. , Weiner J.A. , Apel E.D. , Lewis R.M. , Sanes J.R.
Gene Expr. Patterns4:77-84(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF31
10.

"A single pulse of agrin triggers a pathway that acts to cluster acetylcholine receptors."
Mittaud P. , Camilleri A.A. , Willmann R. , Erb-Voegtli S. , Burden S.J. , Fuhrer C.
Mol. Cell. Biol.24:7841-7854(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACETYLCHOLINE RECEPTOR CLUSTERING
11.

"Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction."
Cheusova T. , Khan M.A. , Schubert S.W. , Gavin A.C. , Buchou T. , Jacob G. , Sticht H. , Allende J. , Boldyreff B. , Brenner H.R. , Hashemolhosseini S.
Genes Dev.20:1800-1816(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;PHOSPHORYLATION AT SER-680 AND SER-697 BY CK2;INTERACTION WITH CSNK2B
12.

"The muscle protein Dok-7 is essential for neuromuscular synaptogenesis."
Okada K. , Inoue A. , Okada M. , Murata Y. , Kakuta S. , Jigami T. , Kubo S. , Shiraishi H. , Eguchi K. , Motomura M. , Akiyama T. , Iwakura Y. , Higuchi O. , Yamanashi Y.
Science312:1802-1805(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DOK7;PHOSPHORYLATION AT TYR-553;MUTAGENESIS OF TYR-553
13.

"Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction."
Lu Z. , Je H.S. , Young P. , Gross J. , Lu B. , Feng G.
J. Cell Biol.177:1077-1089(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDZRN3;UBIQUITINATION
14.

"Lrp4 is a receptor for Agrin and forms a complex with MuSK."
Kim N. , Stiegler A.L. , Cameron T.O. , Hallock P.T. , Gomez A.M. , Huang J.H. , Hubbard S.R. , Dustin M.L. , Burden S.J.
Cell135:334-342(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;INTERACTION WITH LRP4
15.

"Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin."
Zhu D. , Yang Z. , Luo Z. , Luo S. , Xiong W.C. , Mei L.
J. Neurosci.28:1688-1696(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NSF
16.

"A mammalian homolog of Drosophila tumorous imaginal discs, Tid1, mediates agrin signaling at the neuromuscular junction."
Linnoila J. , Wang Y. , Yao Y. , Wang Z.Z.
Neuron60:625-641(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNAJA3;SUBCELLULAR LOCATION
17.

"Caveolin-3 promotes nicotinic acetylcholine receptor clustering and regulates neuromuscular junction activity."
Hezel M. , de Groat W.C. , Galbiati F.
Mol. Biol. Cell21:302-310(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CAV3
18.

"The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization."
Bergamin E. , Hallock P.T. , Burden S.J. , Hubbard S.R.
Mol. Cell39:100-109(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 544-556 IN COMPLEX WITH DOK7;INTERACTION WITH DOK7;PHOSPHORYLATION AT TYR-553

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